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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
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Surface active properties of lipid nanocapsules
Celia R A Mouzouvi1,2, Anita Umerska1, André K Bigot3
1'Micro et Nanomédecines biomimétiques-MINT', INSERM U1066 Université d'Angers, CNRS 6021, Université Bretagne Loire, Angers, France.
Plos One
|August 11, 2017
Summary
Lipid nanocapsules (LNCs) demonstrate significant surface activity, effectively reducing surface tension more than their components. These findings highlight LNCs
Area of Science:
- * Colloid and Surface Science
- * Nanotechnology
- * Materials Science
Background:
- * Lipid nanocapsules (LNCs) are versatile biomimetic nanocarriers with both hydrophilic and hydrophobic moieties.
- * Components like macrogol 15 hydroxystearate (MHS) and lecithin contribute to the surface-active properties of LNCs.
Purpose of the Study:
- * To investigate the surface tension-reducing capabilities of LNCs.
- * To compare the surface activity of LNCs with their constituent ingredients.
Main Methods:
- * Preparation of LNCs (30-100 nm) via phase inversion.
- * Surface tension measurement using drop tensiometry and the Wilhelmy plate method.
Main Results:
- * LNCs achieved lower limiting surface tension (34.8-35.0 mN/m) than MHS (37.7-38.8 mN/m).
- * LNCs exhibited a saturated interfacial concentration (SIC) 10-fold higher than MHS's critical micellar concentration (CMC).
- * SIC of LNCs depended on MHS/triglyceride ratio, not lecithin presence.
Conclusions:
- * LNCs possess inherent surfactant-like properties.
- * These properties suggest potential for novel medical and pharmaceutical applications.
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