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Bilateral internal thoracic arteries: what is the State of the ART?
Bobby Yanagawa1, Subodh Verma, John D Puskas
1aDivision of Cardiac Surgery, St Michael's Hospital, Toronto, Ontario, CanadabDepartment of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Insights
Bilateral internal thoracic artery (BITA) grafting offers protective benefits in coronary artery bypass grafting, despite potential sternal complications. Wider adoption is recommended, pending long-term trial results.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Surgical Innovation
Background:
- Coronary artery bypass grafting (CABG) is a cornerstone treatment for coronary artery disease.
- The use of bilateral internal thoracic artery (BITA) grafts in CABG has been debated due to potential benefits and risks.
- Evidence synthesis is crucial for optimizing surgical strategies in CABG.
Purpose of the Study:
- To review the current evidence on the use of BITA in CABG.
- To evaluate the efficacy, safety, and outcomes associated with BITA grafting.
- To inform clinical practice and future research directions in arterial revascularization.
Main Methods:
- Comprehensive literature review of observational studies and clinical trials.
- Analysis of graft patency, clinical outcomes, and complications associated with BITA use.
- Examination of data from the Arterial Revascularization Trial (ART).
Main Results:
- Observational data predominantly support BITA use, showing protective effects on graft patency and clinical outcomes.
- No significant difference in outcomes based on the specific configuration of BITA grafting.
- Increased risk of sternal complications is a concern, but can be mitigated with sternal-sparing techniques.
- Interim ART results at 5 years did not demonstrate a clinical benefit for BITA over single internal thoracic artery, with final results pending.
Conclusions:
- Current literature supports the use of BITA for surgical revascularization in CABG.
- Anticipation of long-term results from the Arterial Revascularization Trial is high.
- A consensus suggests increasing the proportion of CABG procedures utilizing BITA grafts.
Purpose Of Review:
To provide a broad overview of the current state of knowledge of coronary artery bypass grafting with bilateral internal thoracic artery (BITA).
Recent Findings:
There exists a large body of literature from mostly observational studies supporting the use of BITA in patients undergoing coronary artery bypass grafting but selection bias is a major issue with nonrandomized data. The precise method of BITA use does not appear to impact graft patency nor clinical outcomes - in other words, BITA in any configuration appears to be protective. The major downside is the increased risk of sternal complications, which can be mitigated with sternal-sparring adjuncts. The 5-year interim results of the landmark Arterial Revascularization Trial comparing BITA versus single internal thoracic artery did not show a clinical benefit for BITA but the end-of-trial results are pending. Despite wide guideline support for BITA use, uptake in the surgical community remains low and this is likely because of technical and institutional barriers.
Summary:
The published literature thus far supports surgical revascularization with BITA and we eagerly await the 10-year Arterial Revascularization Trial results. The general consensus is that a greater proportion of surgical revascularization should be performed using BITA.
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