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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

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Allergic and Noninvasive Infectious Pulmonary Aspergillosis Syndromes

Eavan G Muldoon1, Mary E Strek2, Karen C Patterson3

  • 1National Aspergillosis Centre, University Hospital of South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.

Clinics in Chest Medicine
|August 12, 2017
PubMed

Insights

Aspergillosis, a fungal disease, affects many globally. This review focuses on noninvasive forms like allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization, offering updated diagnostic and management strategies.

Area of Science:

  • Medical Mycology
  • Pulmonology
  • Infectious Diseases

Background:

  • Aspergillus species are widespread environmental fungi.
  • Inhalation of Aspergillus spores is common, but disease typically occurs in immunocompromised individuals.
  • Noninvasive aspergillosis, particularly allergic forms, represents a significant global health burden, often overlooked compared to invasive disease.

Purpose of the Study:

  • To provide an updated overview of allergic aspergilloses.
  • To detail the diagnosis and management of allergic bronchopulmonary aspergillosis (ABPA), including in cystic fibrosis patients.
  • To review the presentation, investigation, and management of noninvasive infectious aspergilloses.

Main Methods:

  • Literature review focusing on allergic and noninvasive infectious aspergillosis.
  • Synthesis of current diagnostic criteria and treatment guidelines.
  • Discussion of recent advancements in understanding fungal sensitization and asthma.

Main Results:

  • Allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization are significant clinical entities.
  • Updated diagnostic approaches for ABPA, especially in cystic fibrosis, are presented.
  • Noninvasive infectious aspergilloses require specific diagnostic and management strategies distinct from invasive disease.

Conclusions:

  • Noninvasive aspergilloses, including allergic conditions, are prevalent and require focused clinical attention.
  • Current evidence supports updated diagnostic and management protocols for ABPA and severe asthma with fungal sensitization.
  • Further research into the pathogenesis and treatment of noninvasive aspergilloses is warranted.
Keywords:
ABPAAspergillusAspergillus bronchitisChronic fungal infection of lung

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