Related Experiment Video
Updated: Feb 24, 2026
02:49
Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
Published on: February 23, 2024
2.1K
Cardiovascular risk profile in burn survivors
Becky Leung1, John F Younger2, Kellie Stockton3
1Gold Coast University Hospital, Southport, Gold Coast, Australia; Burns, Trauma and Critical Care Research Centre, School of Medicine, University of Queensland, Brisbane, Herston 4029, Australia.
Burns : Journal of the International Society for Burn Injuries
|August 12, 2017
Summary
Adult burn survivors show altered lipid profiles, with higher triglycerides and lower HDL, influenced by burn severity. However, overall cardiovascular disease risk remains low, and exercise may improve lipid levels.
Area of Science:
- Cardiology
- Metabolic Medicine
- Burn Injury Research
Background:
- Burn injuries cause long-term metabolic and cardiovascular system derangements.
- Limited research exists on cardiovascular disease (CVD) risk in burn survivors.
- Understanding lipid profiles is crucial for assessing long-term health post-burn.
Purpose of the Study:
- To assess lipid profiles in adult burn survivors.
- To evaluate the cardiovascular disease (CVD) risk in this population.
- To identify factors associated with altered lipid values after burn injury.
Main Methods:
- Cross-sectional study of adult burn survivors (18-80% TBSA).
- Lipid measurements (total cholesterol, LDL, HDL, triglycerides) and Framingham General Cardiovascular Risk Score (FGCRS) calculation.
- Multivariate regression analysis to correlate lipids with age, years post-burn, and TBSA.
Main Results:
- Patients exhibited low HDL and high triglycerides compared to optimal values.
- Increased TBSA correlated with higher triglycerides and total cholesterol/HDL ratio.
- The majority (82%) of patients had a low 10-year CVD risk (median FGCRS 3.9%).
- Physical activity was associated with optimal lipid values, irrespective of TBSA.
Conclusions:
- Burn survivors display lipid profile changes proportional to TBSA.
- Exercise may positively influence lipid profiles in burn survivors.
- This study found no increased overall CVD risk in adult burn survivors, suggesting a need for further longitudinal research.
Related Concept Videos
01:22Burn Injuries
4.8K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.8K
01:20Exercise and Cardiovascular Response
4.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.7K
01:23Assessment of the Cardiovascular System I: Subjective Data
952
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
952
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
973
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
973
01:30Coronary Artery Disease I: Introduction
1.3K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.3K
01:29Assessment of the Cardiovascular System II: Inspection
954
Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck
Head and Neck
954