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Related Concept Videos

Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Related Experiment Video

Updated: Feb 24, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
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LungMAP: The Molecular Atlas of Lung Development Program.

Maryanne E Ardini-Poleske1, Robert F Clark2, Charles Ansong3

  • 1RTI International, Research Triangle Park, North Carolina.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|August 12, 2017
PubMed
Summary

LungMAP is creating a molecular atlas of lung development using human and mouse data. This resource aids research into lung formation, injury repair, and regeneration for improved infant survival and adult lung health.

Keywords:
3D imaginglung developmentlung imaginglung omicssingle cell analysisweb resource

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Area of Science:

  • Developmental Biology
  • Genomics
  • Bioinformatics

Background:

  • Lung development is complex, involving intricate gene networks and cell interactions.
  • Understanding lung development, especially alveologenesis, is crucial for premature infant survival and adult lung repair.

Purpose of the Study:

  • To create a molecular atlas of lung development (LungMAP) as a research and educational resource.
  • To facilitate understanding of lung development, injury, and regeneration.

Main Methods:

  • A consortium integrated data from four research centers, a data coordinating center, and a human tissue repository.
  • Collected and analyzed high-quality molecular data (transcriptomic, proteomic, lipidomic) from developing human and mouse lungs.
  • Developed a comprehensive lung ontology and a web portal for data sharing and visualization.

Main Results:

  • LungMAP provides over 6,000 high-resolution images and extensive molecular data for human and mouse lungs.
  • The resource enables cross-species correlation of developmental processes.
  • A public web portal disseminates findings and shares datasets.

Conclusions:

  • LungMAP serves as a valuable public resource for lung development research.
  • The atlas supports studies on lung formation, injury repair, and regeneration.
  • It aims to advance scientific understanding and inspire future researchers.