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Related Experiment Video

Updated: Feb 24, 2026

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
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Gold Nanorod-assisted Optical Stimulation of Neuronal Cells

Published on: April 27, 2015

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Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells.

Parveen Bazard1,2, Robert D Frisina1,3,2, Joseph P Walton1,3,2

  • 1Department of Chemical and Biomedical Engineering, College of Engineering, University of South Florida, Tampa, FL-33620, USA.

Scientific Reports
|August 12, 2017
PubMed
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New nanoparticle-coated nanoelectrodes enable precise neural stimulation using light. This breakthrough offers high spatial resolution for advanced neural prosthetic devices and biomedical implants.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Current neural prosthetic devices lack precise stimulation due to electrical stimulation's limited spatial resolution.
  • Developing sensory and neural prosthetics with improved point stimulation capabilities is crucial.

Purpose of the Study:

  • To present a novel visible light stimulation method for modulating electrically-excitable cells.
  • To demonstrate the potential of gold nanoparticle-coated nanoelectrodes for high-resolution neural prosthetics.

Main Methods:

  • Utilized gold (Au) nanoparticle-coated nanoelectrodes for in-vitro studies.
  • Coated micropipettes with Au nanoparticles using aminosilane linkers.
  • Applied the method to modulate action potential firing patterns in SH-SY5Y neuroblastoma cells and neonatal cardiomyocytes.

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Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
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Optical Control of Living Cells Electrical Activity by Conjugated Polymers
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Related Experiment Videos

Last Updated: Feb 24, 2026

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
09:31

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells

Published on: April 27, 2015

9.4K
Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
09:29

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Published on: September 27, 2011

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Optical Control of Living Cells Electrical Activity by Conjugated Polymers
10:16

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Published on: January 28, 2016

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Main Results:

  • Demonstrated visible light stimulation via surface plasmon resonance for precise cellular activity modulation.
  • Showcased high spatial resolution capabilities of nanoparticle-coated nanoelectrodes.
  • Successfully stimulated and inhibited neuronal and cardiomyocyte firing patterns.

Conclusions:

  • The developed light stimulation method using Au nanoparticle-coated nanoelectrodes shows significant potential for next-generation neural prosthetics.
  • This technology enables temporally and spatially precise excitation and inhibition of electrically-excitable cells.
  • Paves the way for advanced biomedical implants and neural testing devices.