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Portable wireless electrocorticography system with a flexible microelectrodes array for epilepsy treatment.

Kejun Xie¹, Shaomin Zhang^2,3, Shurong Dong¹

¹Key Laboratory of Micro-nano Electronic Devices and Smart Systems of Zhejiang Province, College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou, 310027, China.

Scientific Reports

|August 12, 2017

Summary

This study introduces a portable wireless electrocorticography (ECoG) system for brain activity monitoring and lesion stimulation. The system accurately records and transmits brain signals, demonstrating potential for epilepsy detection and treatment.

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Area of Science:

Neuroscience
Biomedical Engineering
Medical Devices

Background:

Electrocorticography (ECoG) is crucial for understanding brain activity.
Existing ECoG systems can be invasive and lack portability.
Need for advanced, wireless solutions for real-time brain monitoring.

Purpose of the Study:

To develop a portable wireless ECoG system.
To enable real-time brain activity recording and lesion stimulation.
To demonstrate the system's efficacy in detecting and treating epilepsy.

Main Methods:

Utilized a 32-channel flexible ECoG electrode array.
Designed integrated circuits for signal acquisition, processing, and Bluetooth Low Energy 4 transmission.
Conducted in-vivo experiments on rats for system validation.

Main Results:

The system achieved accurate recording of brain activity signals.
Wireless transmission to a cell phone was successful at a maximal sampling rate of 30 kS/s per channel.
Demonstrated detection, localization, and potential treatment of epilepsy lesions.

Conclusions:

The wireless ECoG system offers low energy consumption and high spatial resolution.
This technology shows significant promise for future clinical applications in epilepsy management.
The portable system facilitates advanced brain-computer interfaces and neurological disorder treatments.