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Published on: January 24, 2025
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Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A
Konstantinos Bromis1, Kostakis Gkiatis1, Irene Karanasiou2
1School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.
Computational and Mathematical Methods in Medicine
|August 12, 2017
Summary
Chemotherapy may negatively impact brain function in small-cell lung cancer (SCLC) patients. Resting-state fMRI revealed functional connectivity deficits in key brain networks, suggesting potential cognitive impairments before prophylactic cranial irradiation.
Area of Science:
- Neuroscience
- Oncology
- Radiology
Background:
- Small-cell lung cancer (SCLC) research often focuses on neurocognitive deficits from prophylactic cranial irradiation (PCI).
- Functional brain alterations due to chemotherapy in SCLC patients prior to PCI remain understudied.
- Chemotherapy's impact on cognitive function is a growing concern in cancer treatment.
Purpose of the Study:
- To investigate functional brain connectivity disruptions in SCLC patients post-chemotherapy, before PCI.
- To examine alterations in the Default Mode Network (DMN), Sensorimotor Network, and Task-Positive Network (TPN).
Main Methods:
- Utilized resting-state functional Magnetic Resonance Imaging (fMRI).
- Recruited 19 SCLC patients treated with platinum-based chemotherapy and 13 healthy controls.
- Performed Region of Interest-to-Region of Interest (ROI-to-ROI) and Seed-to-Voxel analyses.
Main Results:
- Identified significant functional connectivity deficits in SCLC patients across all investigated brain networks (DMN, Sensorimotor, TPN).
- Observed widespread disruptions suggesting chemotherapy's potential negative effect on brain function.
- Results indicate chemotherapy-induced changes may precede PCI effects.
Conclusions:
- Chemotherapy treatment in SCLC patients is associated with functional brain connectivity deficits.
- These findings highlight potential chemotherapy-related cognitive impairments in SCLC.
- Further research is warranted to understand and mitigate these effects.
