Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nitric Oxide-Releasing Surfaces Reduce Thrombosis in Venovenous Extracorporeal Life Support: A 5 day Long Ovine Study.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Recovery model for minimally invasive central cannulation, cardiopulmonary bypass, and cardioplegic arrest in quadrupeds.

Perfusion·2024
Same author

The role of fetal hemoglobin in the artificial placenta: A premature ovine model.

Perfusion·2024
Same author

Prolonged (24-hour) Normothermic ex vivo Heart Perfusion Facilitated by Perfusate Hemofiltration.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2022
Same author

Novel Left Atrial Cannulation Technique for Attachment of a Pumpless Artificial Lung.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2022
Same author

Delivery system can vary ventilatory parameters across multiple patients from a single source of mechanical ventilation.

PloS one·2020

Related Experiment Video

Updated: Feb 24, 2026

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
09:39

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

Published on: May 9, 2016

8.4K

A small-scale, rolled-membrane microfluidic artificial lung designed towards future large area manufacturing.

A J Thompson, L H Marks1, M J Goudie2

  • 1VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA.

Biomicrofluidics
|August 12, 2017
PubMed
Summary

A novel manufacturing technique enables scalable production of microfluidic artificial lungs. This continuous rolling and bonding method from a single PDMS layer achieves high gas transfer efficiency for potential human applications.

More Related Videos

Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor
16:45

Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor

Published on: December 15, 2013

10.3K
Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

27.6K

Related Experiment Videos

Last Updated: Feb 24, 2026

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
09:39

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

Published on: May 9, 2016

8.4K
Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor
16:45

Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor

Published on: December 15, 2013

10.3K
Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

27.6K

Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Artificial lungs supplement pulmonary function, with microfluidic artificial lungs (μAL) offering high surface area and biomimetic flow.
  • Current μAL manufacturing limits scalability for human applications despite demonstrated gas transfer efficiencies.

Purpose of the Study:

  • To present a new, scalable manufacturing technology for microfluidic artificial lungs using a continuous rolling and bonding procedure.
  • To evaluate the gas transfer efficiency and pressure drop of μAL fabricated with this novel method.

Main Methods:

  • A continuous "rolling" and bonding procedure assembled a four-layer polydimethyl siloxane (PDMS) device from a single patterned layer.
  • The device featured a biomimetic branching blood flow network, 10 μm artificial capillaries, and a 66 μm gas transfer membrane.
  • Gas transfer efficiency was assessed using blood at flow rates of 0.1-1.25 ml/min with pure O2 and atmospheric air as sweep gases.

Main Results:

  • The fabricated μAL demonstrated gas transfer efficiencies closely matching theoretical predictions for oxygenation and CO2 removal.
  • Observed pressure drops were marginally higher than theoretically predicted values.
  • The manufacturing method proved effective for a small-scale device and is expected to scale to larger areas.

Conclusions:

  • The presented rolling and bonding technique offers a scalable manufacturing solution for microfluidic artificial lungs.
  • This method is the first capable of easily creating large-area microfluidic devices from PDMS, paving the way for clinical translation.
  • Further development is needed to optimize pressure drop and fully realize the potential of these scalable μAL.