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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Fast-responsive hydrogel as an injectable pump for rapid on-demand fluidic flow control.

Rongcong Luo¹, Ngoc-Duy Dinh¹, Chia-Hung Chen

¹Department of Biomedical Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077.

Biomicrofluidics

|August 12, 2017

Summary

Researchers developed fast-responding hydrogels for microfluidic pumps and valves. These novel hydrogels offer precise fluid control and on-demand droplet generation using light stimuli.

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High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Area of Science:

Materials Science
Microfluidics
Chemical Engineering

Background:

Functional hydrogels are promising for microfluidic systems but suffer from slow response times.
Effective fluidic flow control in micro-systems requires rapid hydrogel dynamics.

Purpose of the Study:

To develop a novel porous hydrogel with fast response dynamics for microfluidic applications.
To create photo-responsive composite hydrogels for remotely triggered fluidic regulation.

Main Methods:

A two-step hydrothermal phase separation process using a heterobifunctional crosslinker (4-hydroxybutyl acrylate).
Incorporation of polypyrrole nanoparticles as photothermal transducers to create a photo-responsive composite hydrogel.

Main Results:

The synthesized hydrogel exhibited a significant size reduction (approx. 70%) within 30 seconds upon heating.
The photo-responsive composite hydrogel demonstrated remotely triggerable fluidic regulation and pumping.
On-demand water-in-oil droplet generation was achieved, with droplet size tunable by laser parameters.

Conclusions:

Fast-responding, porous hydrogels can be fabricated using a two-step hydrothermal phase separation method.
Photo-responsive composite hydrogels offer precise, on-demand fluidic control for microfluidic devices.
This technology enables programmable manipulation of fluid flow and droplet generation in micro-systems.