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Updated: Feb 24, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
Intrachiasmatic abscess caused by IgG4-related hypophysitis
Georgios F Hadjigeorgiou1, Eva Løbner Lund2, Lars Poulsgaard3
1Department of Neurosurgery, Academic Hospital Munich-Bogenhausen, Technical University of Munich, Munich, Germany. georgehadji@gmail.com.
Introduction:
Autoimmune hypophysitis is a rare disease of the pituitary, which may affect vision by inflammation and compression of the optic chiasm. However, intrachiasmatic abscess formation has not been previously reported.
Methods:
In this study, we report a case of a 29-year-old female with bitemporal hemianopia due to a cystic intrasellar tumor. The patient underwent surgical decompression of the lesion, which was found to be an intrachiasmatic abscess.
Results:
The histologic findings were consistent with IgG4 hypophysitis.
Conclusion:
This rare clinical presentation suggests that in case of a disproportionate degree of visual impairment in relation to the size of the lesion, suspicion should lead to an intrachiasmatic lesion.
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