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Association between Apo B Levels in Mothers and in their Pre-school Age Offspring

Valeria Hirschler1, Maximiliano Martin2, Karen Oestreicher1

  • 1University of Buenos Aires, Buenos Aires, Argentina.

Cardiovascular & Hematological Agents in Medicinal Chemistry
|August 12, 2017
PubMed

Insights

Maternal apolipoprotein B (apo B) levels are linked to offspring apo B levels in preschool children. This association suggests a potential early indicator for cardiovascular health risk transmission from mother to child.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Health
  • Metabolic Research

Background:

  • Apolipoprotein B (apo B) is a key component of atherogenic lipoproteins.
  • Understanding early life factors influencing apo B levels is crucial for cardiovascular disease prevention.
  • Maternal health status may impact offspring's metabolic profiles.

Purpose of the Study:

  • To investigate the association between maternal and preschool-aged offspring apolipoprotein B (apo B) levels.
  • To explore potential intergenerational transmission of cardiovascular risk markers.

Main Methods:

  • Cross-sectional study involving 84 mother-child pairs in Buenos Aires.
  • Measurements included anthropometrics (BMI), lipids, lipoproteins, and apolipoproteins (apo B).
  • Multiple linear regression analysis was used to assess associations, adjusting for confounders.

Main Results:

  • Maternal apo B levels were significantly associated with offspring apo B levels (Beta=0.29, p=0.03).
  • Offspring of mothers with high apo B levels were 5.7 times more likely to have high apo B levels.
  • Prevalence of overweight and obesity was notable in both mothers and children.

Conclusions:

  • Maternal apo B levels are a significant predictor of apo B concentration in preschool-aged children.
  • Findings suggest a potential link in the early transmission of metabolic and cardiovascular risk factors.
  • Further research is warranted to explore the long-term implications of this association.
Abstract

Keywords:
BMICardiovascular diseaseapo Bdyslipidemiamotherspre-school children

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