Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

838
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
838
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

986
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
986
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

26
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
26
Physical Properties of Alcohols and Phenols02:32

Physical Properties of Alcohols and Phenols

16.9K
Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
Alcohols possess a higher boiling point than aliphatic hydrocarbons of similar...
16.9K
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems01:19

Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems

827
Phase I biotransformation reactions are integral to drug metabolism, predominantly involving oxidative, reductive, and hydrolytic transformations. Chief among these are oxidative reactions, which enhance the hydrophilicity of xenobiotics and introduce polar functional groups to facilitate their elimination from the body.
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
827
Structure and Nomenclature of Alcohols and Phenols02:23

Structure and Nomenclature of Alcohols and Phenols

22.9K
Overview
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and...
22.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Drug affinity-responsive target stability unveils filamins as biological targets for artemetin, an anti-cancer flavonoid.

Frontiers in molecular biosciences·2026
Same author

Immunomodulatory Effects of Nintedanib on Human Blood Monocytes/Macrophages from Patients with Idiopathic Pulmonary Fibrosis.

Biomolecules·2026
Same author

Exploring the chemical space around Cannabis sativa L. leaves as a source of bioactive compounds of pharmaceutical interest.

Scientific reports·2026
Same author

Dietary Terpenoid Lactones are Promiscuous Agonists of Bitter Taste Receptors (TAS2Rs).

Journal of natural products·2026
Same author

Alginate-Based Beads Containing <i>Artemisia absinthium</i> L. Extract as Innovative Ingredients for Baked Products.

Gels (Basel, Switzerland)·2026
Same author

<i>Athamanta sicula</i> L. Root extract: <i>in vitro</i> and <i>in silico</i> evaluation of anti-diabetic and anti-Alzheimer's activities of apiol and myristicin.

Natural product research·2026

Related Experiment Video

Updated: Feb 24, 2026

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

585

Cannabis Phenolics and their Bioactivities.

Federica Pollastro1, Alberto Minassi1, Luigia Grazia Fresu2

  • 1Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy.

Current Medicinal Chemistry
|August 12, 2017
PubMed
Summary

Cannabis sativa L. contains numerous non-cannabinoid polyphenols with significant pharmacological value. These compounds, including flavonoids and lignanamides, contribute to the plant's medicinal and nutritional benefits beyond major cannabinoids.

Keywords:
Cannabis sativa LNon-cannabinoidsantioxidantflavonoidslignansspiroindans.

More Related Videos

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
05:46

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass

Published on: May 27, 2022

7.0K
A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
10:30

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

Published on: June 10, 2022

8.2K

Related Experiment Videos

Last Updated: Feb 24, 2026

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

585
Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
05:46

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass

Published on: May 27, 2022

7.0K
A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
10:30

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

Published on: June 10, 2022

8.2K

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Medicinal Botany

Background:

  • Cannabis sativa L. is recognized for its diverse applications, including medicinal and nutritional uses.
  • Biomedical research has primarily focused on major cannabinoids, overlooking other constituents.
  • Cannabis contains a wide array of non-cannabinoid compounds such as flavonoids, spiroindans, and lignanamides.

Purpose of the Study:

  • To identify polyphenols within Cannabis sativa.
  • To investigate the biosynthesis, bioactivities, and synthesis of these polyphenols.
  • To highlight the broader phytochemical profile of cannabis beyond cannabinoids.

Main Methods:

  • Systematic literature research of bibliographic databases.
  • Focus on non-cannabinoid phenolics across various Cannabis sativa strains.
  • Inclusion of studies on isolation, structural elucidation, biological activity, and synthesis.

Main Results:

  • Cannabis produces over 480 chemical entities, spanning diverse biogenetic classes.
  • Phenolic compounds include unique non-cannabinoid second metabolites.
  • Notable examples include prenylated flavonoids, stilbenoid derivatives, and lignanamides.

Conclusions:

  • Cannabis possesses significant pharmacological and nutritional value attributed to both cannabinoids and non-cannabinoid compounds.
  • Non-cannabinoid constituents play a crucial role in the plant's overall therapeutic potential.
  • Synergistic interactions between cannabinoids and non-cannabinoids may enhance therapeutic effects and mitigate side effects.