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Related Experiment Video

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Hygroscopic sonographically detectable clips form characteristic breast and lymph node pseudocysts.

Moshe Carmon1, Sofia Zilber2, David Gekhtman3

  • 1Breast Health Unit, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
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PubMed
Summary

Hygroscopic sonographically detectable clips (HSDCs) used in breast cancer treatment create a distinct pseudocystic appearance in pathology specimens. Pathologists can identify these HSDC sites, distinguishing them from other lesions for accurate reporting.

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Hygroscopic sonographically detectable clips (HSDCs) are increasingly used in breast cancer management, particularly after neoadjuvant chemotherapy.
  • Accurate identification of clip sites in histopathology is crucial for patient care and interdisciplinary communication.

Purpose of the Study:

  • To characterize the histopathological appearance of HSDC sites in breast and lymph node specimens.
  • To assist pathologists in recognizing and differentiating HSDC sites from other breast lesions.

Main Methods:

  • Analysis of 124 breast cancer specimens (88 breast, 36 lymph nodes) with documented HSDC application.
  • Histopathological examination to evaluate the morphology of the clip sites.

Main Results:

  • HSDC sites were detected in 90% of breast and 81% of lymph node specimens.
  • A characteristic pseudocystic appearance with epithelioid histiocytes was observed in most HSDC sites (69 breast, 23 lymph nodes).
  • Other findings included scarring and macrophages, typical of older clip sites.

Conclusions:

  • HSDC sites exhibit a specific histopathological appearance, primarily a pseudocyst lined by epithelioid histiocytes.
  • Pathologists can recognize these characteristic findings, aiding in accurate diagnosis and reporting.
  • Recognizing HSDC sites is vital for effective communication among healthcare professionals involved in breast cancer treatment.