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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
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Adapting to obesity with adipose tissue inflammation
Shannon M Reilly1, Alan R Saltiel1
1Department of Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA.
Nature Reviews. Endocrinology
|August 12, 2017
Summary
Obesity triggers inflammation in fat tissue, leading to insulin resistance and metabolic inflexibility. This review explores causes, consequences, and anti-inflammatory treatments for obesity-associated metabolic disease.
Area of Science:
- Metabolic disease
- Obesity research
- Adipose tissue biology
Background:
- Adipose tissue stores nutrients and regulates energy balance.
- Overnutrition causes fat accumulation and cellular stress in adipocytes.
- Obesity-induced adipose tissue inflammation is a key factor in metabolic dysfunction.
Purpose of the Study:
- To characterize adipose tissue inflammation in obesity.
- To review triggers of obesity-associated inflammation.
- To examine links between inflammation, insulin/catecholamine resistance, and metabolic inflexibility.
- To discuss current and novel anti-inflammatory treatments.
Main Methods:
- Literature review of adipose tissue inflammation in obesity.
- Analysis of the relationship between adipose tissue inflammation and metabolic disorders.
- Synthesis of current and emerging therapeutic strategies.
Main Results:
- Obesity leads to adipose tissue inflammation, initially a stress response.
- Adipose tissue inflammation is linked to insulin resistance and catecholamine resistance.
- This results in a state of metabolic inflexibility.
Conclusions:
- Adipose tissue inflammation is a critical driver of obesity-associated metabolic disease.
- Targeting inflammation in adipose tissue holds promise for treating metabolic dysfunction.
- Further research into anti-inflammatory therapies is warranted.
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