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Updated: Feb 24, 2026

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
The Gut Microbiota, Food Science, and Human Nutrition: A Timely Marriage
Michael J Barratt1, Carlito Lebrilla2, Howard-Yana Shapiro3
1Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, MO 63110, USA; Center for Gut Microbiome and Nutrition Research, Washington University in St. Louis, St. Louis, MO 63110, USA.
Abstract:
Analytic advances are enabling more precise definitions of the molecular composition of key food staples incorporated into contemporary diets and how the nutrient landscapes of these staples vary as a function of cultivar and food processing methods. This knowledge, combined with insights about the interrelationship between consumer microbiota configurations and biotransformation of food ingredients, should have a number of effects on agriculture, food production, and strategies for improving the nutritional value of foods and health status. These effects include decision-making about which cultivars of current or future food staples to incorporate into existing and future food systems, and which components of waste streams from current or future food manufacturing processes have nutritional value that is worth capturing. They can also guide which technologies should be applied, or need to be developed, to produce foods that support efficient microbial biotransformation of their ingredients into metabolic products that sustain health.
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