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Surface-Engineered Blood Adsorption Device for Hyperphosphatemia Treatment.

Quan Shi1, Michael Jolly1, Marian G Mccord1,2

  • 1From the Fiber and Polymer Science Program, Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, NC.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|August 12, 2017
PubMed
Summary

Researchers developed a novel textile hemoadsorption device using alumina and trimesic acid (TMA) to treat hyperphosphatemia in kidney disease patients. This phosphate adsorbent fabric (PAF) effectively removed phosphate from blood, showing potential for managing high phosphate levels.

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Area of Science:

  • Biomaterials Science
  • Nephrology
  • Surface Engineering

Background:

  • Hyperphosphatemia is a common complication in end-stage kidney disease (ESKD) patients undergoing hemodialysis.
  • Elevated phosphate levels contribute to significant morbidity and mortality in ESKD.
  • Current phosphate management strategies have limitations, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To develop and characterize a novel textile-based hemoadsorption device for hyperphosphatemia management.
  • To engineer phosphate adsorbent fabrics (PAFs) using alumina and trimesic acid (TMA) for efficient phosphate removal.
  • To evaluate the phosphate adsorption capacity and efficacy of PAFs in biological samples and simulated conditions.

Main Methods:

  • PAFs were fabricated by thermopressing alumina powders onto polyester fabrics and treating with TMA.
  • Phosphate adsorption was assessed using static (buffer, plasma, blood) and dynamic (device prototype) experiments.
  • Phosphate concentrations were quantified using colorimetric assays and an automated clinical analyzer.

Main Results:

  • The optimal processing temperature for TMA-alumina PAFs was 260°C, yielding a loading of ~35 g/m.
  • Maximum phosphate adsorption capacity was ~893 mg/m at 37.5°C and pH 7.4 in buffer, with comparable performance in plasma and whole blood.
  • Dynamic simulations demonstrated a 42% reduction in phosphate concentration from whole blood, confirming high efficacy.

Conclusions:

  • Alumina-TMA treated PAFs demonstrate significant potential for hyperphosphatemia management in hemodialysis-dependent ESKD patients.
  • The developed textile-based hemoadsorbent offers a tunable solution for phosphate removal from biological fluids.
  • This technology represents a promising advancement in treating complications associated with chronic kidney disease.