Factors Associated with Benign Paroxysmal Positional Vertigo: A Chinese Case-Control Study

Area of Science:

• Otolaryngology
• Neurology
• Endocrinology

Background:

• Benign paroxysmal positional vertigo (BPPV) is a prevalent vestibular disorder with successful treatment options.
• Predictive factors for BPPV remain underexplored in clinical settings.
• This study investigates potential predictive markers for BPPV in the Chinese population.

Purpose of the Study:

• To explore potential biochemical and hematological predictive factors for BPPV.
• To identify associations between cardiovascular and cerebrovascular disease history and BPPV.
• To analyze the independent predictive value of specific markers for BPPV.

Main Methods:

• A cohort of 240 BPPV patients was recruited from Beijing Chaoyang Hospital (July 2013 - July 2016).
• Biochemical markers, hematological markers, and medical history were collected.
• Statistical analyses, including multiple logistic regression, were performed to identify significant associations.

Main Results:

• Patients with BPPV exhibited significantly lower serum uric acid (SUA), hemoglobin A1c (HbA1c), albumin, and creatinine levels compared to controls.
• Multiple logistic regression revealed that lower HbA1c (OR 0.680) and albumin (OR 0.338) were independently associated with BPPV.
• Serum uric acid was not found to be an independent risk factor for BPPV (OR 0.999).

Conclusions:

• Reduced levels of hemoglobin A1c (HbA1c) and albumin are independently associated with an increased risk of benign paroxysmal positional vertigo (BPPV).
• While serum uric acid levels were lower in BPPV patients, it did not emerge as an independent predictive factor.
• These findings contribute to understanding potential biomarkers for BPPV risk stratification.