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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
Jennifer Noro1, Ana Loureiro1, Filipa Gonçalves1
1Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
Colloids and Surfaces. B, Biointerfaces
|August 12, 2017
Summary
Modified cyclo-oligosaccharides form stable nanoemulsions for encapsulating amphiphilic molecules like the drug methotrexate (MTX). These novel nanodevices show promise for cosmetic and pharmaceutical applications.
Area of Science:
- Materials Science
- Nanotechnology
- Drug Delivery
Background:
- Cyclo-oligosaccharides (COS) are versatile cyclic carbohydrates.
- Modifying COS with hydrophobic chains enhances their emulsification properties.
- Developing effective nano-carriers is crucial for drug delivery and cosmetics.
Purpose of the Study:
- To synthesize and characterize new nanodevices using modified cyclo-oligosaccharides.
- To evaluate the encapsulation and delivery capabilities of these nanodevices for amphiphilic molecules.
- To assess the potential of these nanodevices for cosmetic and pharmaceutical applications.
Main Methods:
- Synthesis of cyclo-oligosaccharides fully substituted by palmitic chains.
- Emulsification of modified cyclo-oligosaccharides using ultrasound (US).
- Characterization using Nuclear Magnetic Resonance (NMR), Scanning Transmission Electron Microscopy (STEM), and Dynamic Light Scattering (DLS).
- Assessment of methotrexate (MTX) encapsulation and delivery.
Main Results:
- Successfully synthesized hydrophobic cyclo-oligosaccharide derivatives.
- Achieved formation of small and narrow-sized nanoemulsions.
- Demonstrated effective encapsulation and potential delivery of amphiphilic methotrexate (MTX).
- Physicochemical properties confirmed by NMR, STEM, and DLS.
Conclusions:
- Modified cyclo-oligosaccharides are effective platforms for creating nanoemulsions.
- These nanoemulsions can encapsulate amphiphilic compounds like methotrexate.
- The developed nanodevices hold significant potential for cosmetic and pharmaceutical applications.
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