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Related Experiment Video

Updated: Feb 24, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
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First comparative analysis concerning the plasma platelet contamination during MNC collection.

Hella Pfeiffer1, Susanne Achenbach1, Julian Strobel1

  • 1Transfusion Medicine and Haemostaseology Department, University Hospital Erlangen, Germany.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|August 13, 2017
PubMed
Summary

The new Spectra Optia apheresis device significantly reduces platelet contamination in collected plasma. This improved plasma quality, with fewer platelets and leukocytes, may be suitable for fractionation.

Keywords:
Cobe SpectraContaminationPlasmaPlateletSpectra Optia

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Area of Science:

  • Cellular biology
  • Biomedical engineering
  • Hematology

Background:

  • Autologous plasma is used to culture monocytes into dendritic cells.
  • Apheresis processes often contaminate plasma with platelets, impacting dendritic cell maturation.
  • Reducing platelet contamination is crucial for optimal dendritic cell yield.

Purpose of the Study:

  • To evaluate a new apheresis device (Spectra Optia) for its potential to generate source plasma with reduced platelet contamination.
  • To compare the Spectra Optia device against established devices (COM.TEC, Cobe Spectra) regarding platelet contamination in collected plasma.

Main Methods:

  • A prospective study analyzed concurrent plasma from the Spectra Optia device (n=24) for residual cell contamination.
  • Retrospective data from COM.TEC and Cobe Spectra devices (n=72) were used for comparison.
  • The predictive value of pre-donation platelet counts on plasma contamination was assessed.

Main Results:

  • The Spectra Optia device demonstrated the lowest residual platelet count (median 3.50×10^9/l) in collected plasma, irrespective of donor pre-donation counts.
  • Established devices (COM.TEC, Cobe Spectra) exhibited higher platelet contamination.
  • Leukocyte contamination was minimal, with only 2.0% of samples exceeding 0.5×10^9/l.

Conclusions:

  • The Spectra Optia device significantly reduces platelet contamination in concurrently collected plasma.
  • The resulting plasma product, with low platelet and leukocyte levels, shows potential for plasma fractionation applications.