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The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Updated: Feb 24, 2026

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CredibleMeds.org: What does it offer?

Raymond L Woosley1, Kristin Black2, C William Heise3

  • 1Division of Clinical Data Analytics and Decision Support, Department of Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ; AZCERT, Oro Valley, AZ.

Trends in Cardiovascular Medicine
|August 13, 2017
PubMed
Summary
This summary is machine-generated.

CredibleMeds.org provides essential information on drugs that prolong the QT interval and cause torsades de pointes (TdP). This resource aids clinicians and patients in safe medication management and arrhythmia risk assessment.

Keywords:
ArrhythmiaQT intervalQT prolongationSudden deathTorsades de pointes

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Area of Science:

  • Pharmacology
  • Clinical Therapeutics
  • Cardiology

Background:

  • Non-cardiac drugs can prolong the QT interval, increasing the risk of torsades de pointes (TdP) arrhythmias.
  • Assessing drug-induced TdP causality is complex for drugs marketed or in development.

Purpose of the Study:

  • To provide a reliable resource for understanding drug-associated QT prolongation and TdP risk.
  • To support safe medication use and clinical decision-making.

Main Methods:

  • Development of the CredibleMeds.org website and its QTdrugs database.
  • Categorization of over 220 drugs based on QT prolongation and TdP association.
  • Provision of educational resources and mobile accessibility.

Main Results:

  • CredibleMeds.org has become a primary, reliable source for over 96,000 users since 1999.
  • The QTdrugs lists are integrated into clinical decision support systems and prescribing quality metrics.
  • A free smartphone app and API enhance access to drug risk information.

Conclusions:

  • CredibleMeds.org effectively addresses the need for accessible information on QT-prolonging drugs.
  • The resource empowers patients, healthcare providers, and researchers to mitigate risks associated with drug-induced arrhythmias.
  • Continued development and accessibility foster safer medication practices globally.