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Updated: Feb 24, 2026

In Vitro Polymerization of F-actin on Early Endosomes
Published on: August 28, 2017
Following the fate of endocytosed fibrils
Masato Hasegawa1, Genjiro Suzuki2
1From the Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan hasegawa-ms@igakuken.or.jp.
Abstract:
Cell-to-cell transmission of intracellular protein aggregates is considered a central event in many neurodegenerative diseases, but little is known about the underlying molecular mechanisms. A new study employs fluorescence quenching to examine the fate of α-synuclein, a key molecule in the pathology of Parkinson's disease and related disorders, in primary cultured neurons, finding that endocytosis and lysosomal processing of exogenous fibrils may explain the transmission of α-synuclein pathology.
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