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Promoter Activation with Electromagnetism.

Abraham O Rodríguez-De la Fuente1, J Antonio Heredia-Rojas2, Juan M Alcocer-González1

  • 1Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, CP 66455, Mexico.

Methods in Molecular Biology (Clifton, N.J.)
|August 13, 2017
PubMed
Summary

Extremely low-frequency electromagnetic fields can activate gene promoters. This study provides a guide to examine this effect and build a solenoid for promoter activation.

Keywords:
Electromagnetic fieldElectromagnetic field response elementsPromoter activationSynthetic promoter

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Area of Science:

  • Biophysics
  • Molecular Biology
  • Electromagnetism

Background:

  • Gene expression is influenced by physical stimuli, including electromagnetic fields.
  • Specific promoter elements are required for gene activation by electromagnetic fields.

Purpose of the Study:

  • To detail methods for examining promoter activation using extremely low-frequency electromagnetic fields.
  • To provide instructions for constructing a solenoid device for this purpose.

Main Methods:

  • Utilizing a suitable promoter with electromagnetic field response elements.
  • Assembling a solenoid apparatus designed for promoter activation experiments.

Main Results:

  • Demonstrated the feasibility of promoter activation by extremely low-frequency electromagnetic fields.
  • Provided a practical, step-by-step guide for experimental setup.

Conclusions:

  • Extremely low-frequency electromagnetic fields represent a viable physical factor for modulating gene expression.
  • The described methodology and apparatus facilitate research into electromagnetic field-mediated gene regulation.