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Cerebral venous sinus Thrombosis: Clinical Features, Long-Term outcome and recanalization
Sibel Gazioglu1, Ilker Eyuboglu2, Ahmet Yildirim1
1Department of Neurology, Karadeniz Technical University Medical Faculty, 61080 Trabzon, Turkey.
Insights
Cerebral venous sinus thrombosis (CVST) generally has a good prognosis and recanalization rate. Complete or partial recanalization did not impact clinical outcomes in this study.
Area of Science:
- Neurology
- Vascular Medicine
- Radiology
Background:
- Cerebral venous sinus thrombosis (CVST) is a condition affecting brain venous drainage.
- Recanalization and patient prognosis in CVST are typically favorable.
- Factors influencing recanalization require further investigation.
Purpose of the Study:
- To evaluate long-term outcomes, recanalization rates, and associated factors in patients with CVST.
- To assess the relationship between recanalization and clinical outcomes.
- To analyze demographic and clinical data for predictive factors.
Main Methods:
- Retrospective analysis of 50 patients diagnosed with CVST between 2007 and 2016.
- Review of follow-up imaging and modified Rankin scale (mRS) scores at six months for 31 patients with adequate follow-up.
- Univariate analysis to identify factors associated with recanalization.
Main Results:
- A favorable outcome (mRS 0-1) was observed in 83.9% of patients at six months.
- Complete recanalization occurred in 48.4%, partial in 45.2%, and none in 6.5% of cases.
- Higher recanalization rates were noted in female patients (p=0.013) and lower rates in those with multiple dural sinus thrombosis (p=0.03).
Conclusions:
- CVST demonstrates good prognosis and recanalization rates.
- Recanalization status (complete or partial) was not significantly associated with clinical outcomes.
- Female gender and single dural sinus thrombosis may be associated with better recanalization.
Abstract:
Recanalization and prognosis of cerebral venous sinus thrombosis (CVST) are generally considered to be good, and various factors have been reported to be associated with recanalization in previous studies. Fifty patients diagnosed with CVST between September 2007 and July 2016 were analyzed retrospectively. Modified Rankin scale (mRS) scores at six months and results of follow-up imaging of patients with at least six months follow-up were also reviewed for the assessment of long term outcome, recanalization rates and factors associated with recanalization. The mean age of the patients (39 female, 11 male) was 34.6±11.2years (17-69). Of the 50 patients enrolled, 31 (62%) had at least six months follow-up with available data and 26 (83.9%) of these had favorable outcomes (mRS 0-1) at six months. Complete recanalization was observed in 15 patients (48.4%), partial recanalization in 14 (45.2%) and no recanalization in 2 (6.5%). Univariate analysis revealed that complete recanalization rates were higher in female patients (p=0.013) and lower in patients with multiple thrombosis in more than one dural sinus (p=0.03). The prognosis and recanalization rates of CVST were good, and complete or partial recanalization of venous sinuses was not associated with clinical outcome.
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