Cerebral venous sinus Thrombosis: Clinical Features, Long-Term outcome and recanalization

Sibel Gazioglu1, Ilker Eyuboglu2, Ahmet Yildirim1

  • 1Department of Neurology, Karadeniz Technical University Medical Faculty, 61080 Trabzon, Turkey.

Insights

Cerebral venous sinus thrombosis (CVST) generally has a good prognosis and recanalization rate. Complete or partial recanalization did not impact clinical outcomes in this study.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Cerebral venous sinus thrombosis (CVST) is a condition affecting brain venous drainage.
  • Recanalization and patient prognosis in CVST are typically favorable.
  • Factors influencing recanalization require further investigation.

Purpose of the Study:

  • To evaluate long-term outcomes, recanalization rates, and associated factors in patients with CVST.
  • To assess the relationship between recanalization and clinical outcomes.
  • To analyze demographic and clinical data for predictive factors.

Main Methods:

  • Retrospective analysis of 50 patients diagnosed with CVST between 2007 and 2016.
  • Review of follow-up imaging and modified Rankin scale (mRS) scores at six months for 31 patients with adequate follow-up.
  • Univariate analysis to identify factors associated with recanalization.

Main Results:

  • A favorable outcome (mRS 0-1) was observed in 83.9% of patients at six months.
  • Complete recanalization occurred in 48.4%, partial in 45.2%, and none in 6.5% of cases.
  • Higher recanalization rates were noted in female patients (p=0.013) and lower rates in those with multiple dural sinus thrombosis (p=0.03).

Conclusions:

  • CVST demonstrates good prognosis and recanalization rates.
  • Recanalization status (complete or partial) was not significantly associated with clinical outcomes.
  • Female gender and single dural sinus thrombosis may be associated with better recanalization.

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