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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients

Norio Aoyama1, Jun-Ichi Suzuki2,3, Hidetoshi Kumagai4

  • 1Division of Periodontology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaokacho, Yokosuka, Kanagawa, 238-8580, Japan.

Heart and Vessels
|August 14, 2017
PubMed

Insights

Periodontopathic bacteria like Aggregatibacter actinomycetemcomitans may increase hypertension risk in men. This study found higher bacterial detection in male cardiovascular patients with hypertension.

Area of Science:

  • Cardiovascular Health
  • Oral Microbiology
  • Systemic Disease Etiology

Background:

  • Hypertension (HT) significantly impacts quality of life and mortality.
  • Periodontitis is a known risk factor for HT, but causal links remain unclear.

Purpose of the Study:

  • To investigate the association between periodontopathic bacterial infections and hypertension in cardiovascular patients.
  • To identify specific bacterial species potentially linked to hypertension development.

Main Methods:

  • Evaluated three periodontopathic bacteria and their antibody titers in cardiovascular patients with (n=412) and without (n=199) HT.
  • Conducted blood examinations and periodontal measurements.
  • Assessed rates of obesity, dyslipidemia, and diabetes.

Main Results:

  • Aggregatibacter actinomycetemcomitans and Prevotella intermedia were more prevalent in male patients with HT.
  • No significant difference in these bacteria was observed between female patients with and without HT.
  • Elderly male patients with HT exhibited greater mean probing pocket depth.

Conclusions:

  • Specific periodontopathic bacterial infections may contribute to hypertension in male cardiovascular patients.
  • The findings suggest a potential gender-specific role of oral bacteria in hypertension etiology.

Keywords:
BacteriaCardiovascular diseaseHypertensionPeriodontal disease

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