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Perioperative Statins Do Not Prevent Acute Kidney Injury After Cardiac Surgery: A Meta-analysis of Randomized

Bing-Cheng Zhao1, Pu Shen2, Ke-Xuan Liu1

  • 1Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Journal of Cardiothoracic and Vascular Anesthesia
|August 15, 2017
PubMed

Insights

Perioperative statin use does not reduce the risk of acute kidney injury (AKI) after cardiac surgery. This systematic review found no benefit, advising against initiating statins solely for AKI prevention in this patient group.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Acute kidney injury (AKI) is a significant complication following cardiac surgery.
  • Perioperative statin therapy is sometimes used, but its efficacy in preventing AKI remains unclear.

Purpose of the Study:

  • To systematically evaluate the effectiveness of perioperative statins in reducing the incidence of AKI after cardiac surgery.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials.
  • Included adult patients undergoing cardiac surgery, comparing statin therapy with placebo or control.
  • Utilized PubMed, EMBASE, and Cochrane Library databases; performed random-effects meta-analyses and trial sequential analysis.

Main Results:

  • Eight trials with 3,204 patients were analyzed.
  • Perioperative statins showed no significant difference in AKI incidence (RR = 1.02, 95% CI = 0.82-1.28).
  • No significant benefits were observed for renal replacement therapy, ventilation duration, or length of stay; in-hospital mortality showed a non-significant increase (RR = 3.76, 95% CI = 0.93-15.14).

Conclusions:

  • Perioperative statin treatment does not decrease the risk of AKI in patients undergoing cardiac surgery.
  • Statin therapy should not be initiated with the primary goal of preventing AKI post-cardiac surgery.
Abstract

Keywords:
acute kidney injurycardiac surgerymeta-analysisstatin

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