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Ureaplasma urealyticum necrotizing soft tissue infection

Ian Gassiep1, Letitia Gore2, Joanne L Dale3

  • 1Department of Infectious Diseases, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba, QLD, 4102, Australia; School of Medicine, University of Queensland, St Lucia, QLD, 4072, Australia.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|August 15, 2017
PubMed

Insights

Ureaplasma urealyticum can cause rare, severe infections outside the urogenital tract, particularly in immunocompromised patients. Early diagnosis and treatment are crucial for managing these serious Ureaplasma urealyticum soft tissue and joint infections.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Immunology

Background:

  • Ureaplasma urealyticum is a common urogenital bacterium.
  • It is typically associated with localized urogenital infections.
  • Increasing reports link it to non-urogenital infections, especially with advancements in immunosuppressive therapies.

Observation:

  • A rare case of Ureaplasma urealyticum infection is presented.
  • The infection manifested as necrotizing soft tissue infection and septic arthritis of the left hip.
  • The patient was hypogammaglobulinaemic, indicating an immunocompromised state.

Findings:

  • Ureaplasma urealyticum was identified as the causative agent.
  • The infection involved severe soft tissue necrosis and joint destruction.
  • This highlights the potential for Ureaplasma urealyticum to cause invasive, systemic disease.

Implications:

  • Clinicians should consider Ureaplasma urealyticum in non-urogenital infections, particularly in immunocompromised individuals.
  • Early nucleic-acid diagnostic investigations are recommended.
  • Empiric therapy should include agents with activity against Ureaplasma, especially in high-risk patients.
Keywords:
HypogammaglobulinaemiaNecrotizingSoft tissue infectionU. urealyticumUreaplasma

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