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Plasma somatostatin response in normal and gastrectomized subjects
The Tohoku Journal of Experimental Medicine
|October 1, 1986
Summary
The stomach significantly contributes to increased somatostatin-like immunoreactivity (SLI) levels during elevated free fatty acids (FFA). Gastrectomy eliminates this stomach-derived SLI response in humans.
Area of Science:
- Gastroenterology
- Endocrinology
- Human Physiology
Background:
- Somatostatin-like immunoreactivity (SLI) plays a role in regulating gastrointestinal functions.
- The primary source of circulating SLI in humans, especially post-nutrient stimulation, remains incompletely understood.
Purpose of the Study:
- To investigate the stomach's contribution to plasma SLI concentrations in humans.
- To determine if the stomach is the main source of the SLI increase observed during elevated plasma free fatty acids (FFA).
Main Methods:
- Plasma SLI levels were measured in healthy controls and patients who had undergone either total or partial gastrectomy.
- Hyper-fatty-acidemia was induced using a lipid-heparin infusion in all study groups.
- Fasting and post-infusion plasma SLI and FFA levels were compared across groups.
Main Results:
- Fasting plasma SLI levels were similar in gastrectomized subjects and controls.
- In healthy controls, lipid-heparin infusion caused a five-fold increase in plasma SLI.
- Gastrectomized subjects showed no significant increase in plasma SLI despite comparable elevations in plasma FFA.
Conclusions:
- The stomach, particularly the antral region, is the primary source of the plasma SLI increase during induced hyper-fatty-acidemia.
- Following nutrient stimulation, the stomach contributes more significantly to plasma SLI levels than the pancreas or other intestinal regions in humans.