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Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese

Jin Li1,2, Jing Hu3, Rong Sun4

  • 1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.

Disease Markers
|August 15, 2017
PubMed

Insights

The CUL3 gene variant rs17479770 may protect against essential hypertension (EH) in the Chinese Han population. Specifically, the TT genotype and T allele in males showed a decreased risk of developing EH.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Essential hypertension (EH) affects over a billion people globally and is a complex multifactorial disease.
  • While CUL3 gene mutations are linked to secondary hypertension, the role of CUL3 polymorphisms in EH remains unexplored.
  • This study focuses on the Chinese Han population to investigate potential associations.

Purpose of the Study:

  • To investigate the association between CUL3 gene single nucleotide polymorphisms (SNPs) rs17479770 and rs3738952 and essential hypertension (EH).
  • To determine if CUL3 gene variants influence the risk of developing EH in the Chinese Han population.

Main Methods:

  • A case-control study involving 520 participants (259 EH patients, 261 controls).
  • Participants were matched for age, gender, BMI, and key metabolic markers (TG, TC, HbA1c).
  • Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) were used to analyze CUL3 SNPs rs17479770 and rs3738952.

Main Results:

  • No significant differences in allele, genotype, or haplotype distributions were found for rs3738952 or the combined haplotype.
  • The rs17479770 TT genotype was significantly associated with a reduced risk of EH in males and the overall dataset (P=0.050, P=0.042).
  • A trend towards decreased EH risk was observed for the rs17479770 T allele in males (P=0.064).

Conclusions:

  • The CUL3 rs17479770 variant may act as a protective factor in the development of essential hypertension.
  • This specific CUL3 gene variant shows potential as a biomarker for EH risk stratification.
Abstract

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