Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kinins, receptors, antagonists.

D Regoli

    Advances in Experimental Medicine and Biology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Kinins are potent myotropic agents acting on smooth muscle via B1 and B2 receptors. New antagonists offer tools against kinins and tachykinins, crucial in inflammation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bradykinin B₂ receptors increase hippocampal excitability and susceptibility to seizures in mice.

    Neuroscience·2013
    Same author

    Therapeutic options in inflammatory bowel disease: experimental evidence of a beneficial effect of kinin B1 receptor blockade.

    British journal of pharmacology·2008
    Same author

    Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice.

    British journal of pharmacology·2008
    Same author

    Involvement of kinin B1 receptor and oxidative stress in sensory abnormalities and arterial hypertension in an experimental rat model of insulin resistance.

    Neuropeptides·2007
    Same author

    Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.

    The journal of peptide research : official journal of the American Peptide Society·2005
    Same author

    Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice.

    Naunyn-Schmiedeberg's archives of pharmacology·2004

    Area of Science:

    • Pharmacology
    • Physiology
    • Biochemistry

    Background:

    • Kinins are potent myotropic agents affecting various smooth muscle tissues.
    • Two main kinin receptor types, B1 and B2, have been identified.

    Purpose of the Study:

    • To characterize kinin receptor subtypes (B1 and B2) using pharmacological tools.
    • To investigate the mechanisms of kinin action in different smooth muscle preparations.
    • To explore the potential of novel antagonists for therapeutic applications.

    Main Methods:

    • Pharmacological studies involving agonists and antagonists.
    • Binding assays with labeled bradykinin (BK) and desArg9BK.
    • Investigation of kinin action in the presence and absence of enzyme inhibitors (indomethacin, BW 755C).

    Related Experiment Videos

    Main Results:

    • Specific and potent antagonists for B1 receptors were identified.
    • Weak, non-specific antagonists for B2 receptors were found among anti-tachykinin compounds.
    • B1 receptor activation is generally independent of arachidonic acid, while B2 activation involves this pathway.
    • Kinins do not act on sympathetic nerve endings or promote histamine/serotonin release.

    Conclusions:

    • Novel antagonists provide pharmacological tools for studying kinins and tachykinins in inflammation.
    • B2 receptor activation is linked to the arachidonic acid cascade.
    • Kinin actions differ from acetylcholine, particularly regarding lipoxygenase inhibition.