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Whole Blood Platelet Aggregometry.

George A Fritsma1, David L McGlasson2

  • 1The Fritsma Factor, Your Interactive Hemostasis Resource, 153 Redwood Drive, Trussville, AL, 35173, USA. George@fritsmafactor.com.

Methods in Molecular Biology (Clifton, N.J.)
|August 15, 2017
PubMed
Summary

Whole blood impedance lumiaggregometry offers an updated approach to platelet function testing, enhancing reproducibility and enabling near-patient testing. This review details the methodology and discusses three available near-patient systems.

Keywords:
AggregometryImpedance aggregometryLumiaggregometryMultiplatePFA-100PFA-200Platelet aggregationPlatelet function testingQualitative platelet disordersVerifyNowWhole blood platelet aggregometry

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Area of Science:

  • Hematology
  • Clinical Chemistry
  • Biomedical Engineering

Background:

  • Light transmittance aggregometry is the established reference method for platelet function analysis.
  • Whole blood impedance lumiaggregometry presents an advanced alternative with improved features.

Purpose of the Study:

  • To describe whole blood impedance lumiaggregometry and its advantages.
  • To review three distinct near-patient platelet function testing systems.
  • To explore the significance of inter-platform concordance.

Main Methods:

  • Detailed explanation of whole blood impedance lumiaggregometry principles.
  • Description of three near-patient whole blood platelet function testing instruments.
  • Inclusion of operational principles, materials, and example protocols.

Main Results:

  • Whole blood impedance lumiaggregometry offers simplified specimen handling and mimics in vivo conditions.
  • Three near-patient systems utilizing unique technologies are presented.
  • The study speculates on the importance of agreement between different testing platforms.

Conclusions:

  • Whole blood impedance lumiaggregometry is emerging as a standard for platelet function testing.
  • Near-patient testing capabilities enhance accessibility and efficiency.
  • Further investigation into platform concordance is warranted for reliable clinical application.