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Progenitor Cells from Cartilage: Grade Specific Differences in Stem Cell Marker Expression.

Marija Mazor1, Annabelle Cesaro2, Mazen Ali3

  • 1Department of Sciences, University of Orleans, I3MTO, EA 4708, Orleans F-45032, France. mazor.marica@gmail.com.

International Journal of Molecular Sciences
|August 15, 2017
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cell (MSC)-like progenitors (MPC) are present in osteoarthritic cartilage. Mild osteoarthritis samples showed greater MSC potential compared to severe cases, indicated by higher marker expression after in vitro expansion.

Keywords:
cartilagemesenchymal stem cell-like progenitorsosteoarthritic

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Area of Science:

  • Orthopedics
  • Stem Cell Biology
  • Osteoarthritis Research

Background:

  • Mesenchymal stem cell (MSC)-like progenitors (MPC) are found in normal and osteoarthritic cartilage.
  • Limited data exists on how MPC marker expression changes with osteoarthritis (OA) progression.

Purpose of the Study:

  • To compare the prevalence of various MPC markers across different grades of OA.
  • To investigate potential differences in MSC potential between mild and severe OA cartilage.

Main Methods:

  • Human osteoarthritic tibial plateaus were classified into mild or severe OA groups (OARSI scoring).
  • mRNA expression of CD105, CD166, Notch 1, Sox9, Acan, and Col II A1 was measured at day 0 and day 14 in vitro.
  • MSC markers (Nucleostemin, CD90, CD73, CD166, CD105, Notch 1) were analyzed via immunofluorescence.

Main Results:

  • No significant difference in MSC marker mRNA levels between mild and severe OA at day 0.
  • After 14 days in vitro, cells from mild OA showed a significant increase in CD105 and CD166 mRNA.
  • Mild OA cells exhibited higher levels of CD105, Sox9, and Acan compared to severe OA cells.

Conclusions:

  • MSC markers are present at both mRNA and protein levels in mild and severe OA cartilage.
  • Cartilage-derived cells from mild OA demonstrate a potentially greater Mesenchymal stem cell (MSC) potential than those from severe OA.
  • These findings suggest OA severity influences the characteristics and potential of resident MPCs.