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Quantification of Hypopigmentation Activity In Vitro
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New data on hyperpigmentation disorders.

S Schalka1

  • 1Department of Dermatology, Santo Amaro University Medical School, Santo Amaro, Brazil.

Journal of the European Academy of Dermatology and Venereology : JEADV
|August 15, 2017
PubMed
Summary
This summary is machine-generated.

Visible light (VL) and infrared light (IR) contribute to skin hyperpigmentation. Protection involves sunscreens with iron oxides for VL, while IR protection remains limited, with topical antioxidants showing potential but needing further study.

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Area of Science:

  • Dermatology
  • Photobiology
  • Cosmetic Science

Background:

  • Visible light (VL) and infrared light (IR) are increasingly recognized as contributors to skin hyperpigmentation.
  • These light sources can induce melanogenesis and other cellular changes leading to uneven skin tone.

Purpose of the Study:

  • To provide an updated review on the causes of skin hyperpigmentation.
  • To explore current and emerging prevention strategies against UV, VL, and IR light exposure.

Main Methods:

  • Literature review of recent scientific data on hyperpigmentation etiology and prevention.
  • Analysis of the effects of different light spectrums on skin pigmentation.

Main Results:

  • VL significantly impacts pigmentation, especially in certain phototypes, and generates Reactive Oxygen Species (ROS), leading to erythema and DNA damage.
  • IR light is implicated in melanogenesis via specific molecular pathways (endothelin receptor B, MAPK/ERK1/2, p38).
  • Sunscreens with iron oxides are effective against VL-induced hyperpigmentation; systemic antioxidants and novel UV-VL sunscreens may offer additional protection.

Conclusions:

  • UV, VL, and IR radiation all contribute to skin pigmentation.
  • Adequate sun protection is crucial for preventing hyperpigmentation.
  • Current protection against IR is insufficient, though topical antioxidants show promise pending clinical validation.