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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

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Stroke or left atrial thrombus prediction using antithrombin III and mean platelet volume in patients with

Seo-Won Choi1, Bo-Bae Kim2, Dong-Hyun Choi2

  • 1Department of Cardiology, Gwangju Veterans Hospital, Gwangju, Republic of Korea.

Clinical Cardiology
|August 15, 2017
PubMed

Insights

High mean platelet volume (MPV) and antithrombin III (AT-III) deficiency predict stroke or left atrial thrombus in atrial fibrillation (AF) patients. These markers are independent of standard risk scores and treatments.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Current risk scores like CHADS2 and CHA2DS2-VASc have moderate ability to predict thromboembolic events in nonvalvular atrial fibrillation (AF).
  • There is a need for more accurate predictors of stroke and left atrial (LA) thrombus in AF patients.

Purpose of the Study:

  • To investigate the association between antithrombin III (AT-III) deficiency and mean platelet volume (MPV) with stroke or LA thrombus development in AF patients.
  • To assess if AT-III deficiency and MPV can improve stroke risk prediction in AF.

Main Methods:

  • Analyzed AT-III levels and MPV in 352 AF patients.
  • Assessed the composite endpoint of ischemic stroke and incidental LA thrombus over a mean follow-up of 35.4 months.
  • Utilized Cox proportional hazard analysis to identify independent predictors.

Main Results:

  • A higher rate of stroke or LA thrombus was observed in patients with low AT-III (<70%) and high MPV (≥7.0 fL).
  • AF patients with both high MPV and AT-III deficiency showed increased risk.
  • High MPV was an independent predictor of stroke or LA thrombus (HR: 6.408).

Conclusions:

  • Elevated MPV and AT-III deficiency are significant predictive markers for stroke or LA thrombus in AF patients.
  • These markers demonstrate predictive value independent of antiplatelet therapy, anticoagulation, and CHA2DS2-VASc scores.
  • MPV and AT-III deficiency may enhance risk stratification for thromboembolic events in AF.
Abstract

Keywords:
Antithrombin IIIAtrial FibrillationLeft Atrial ThrombusMean Platelet VolumeStroke

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