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Lessons from Interspecies Mammalian Chimeras.

Fabian Suchy¹, Hiromitsu Nakauchi^1,2

¹Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305;

Annual Review of Cell and Developmental Biology

|August 15, 2017

Summary

Chimeras, once mythical creatures, are now vital tools in bioscience. Advances in stem cell biology and interspecies chimerism enable new models for developmental biology and the creation of patient-specific organs for transplantation.

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Area of Science:

Developmental Biology
Evolutionary Biology
Regenerative Medicine
Stem Cell Biology

Background:

Chimeras, organisms composed of cells from different zygotes, have evolved from mythological concepts to powerful scientific models.
Recent breakthroughs in stem cell biology have significantly advanced the potential of chimerism research.

Purpose of the Study:

To explore how chimeras are revolutionizing developmental biology and evolutionary divergence studies.
To highlight the translational applications of contemporary chimerism, particularly in organ generation.

Main Methods:

Utilizing advances in stem cell biology.
Developing interspecies chimerism models.
Investigating developmental processes and evolutionary pathways.

Keywords:

chimera interspecies organ niche organogenesis pluripotency

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Main Results:

Revealing fundamental secrets of developmental biology.
Providing insights into evolutionary divergence mechanisms.
Establishing novel models with broad basic and translational applications.

Conclusions:

Chimeras are indispensable tools in modern bioscience.
Interspecies chimerism facilitates the generation of patient-specific organs for transplantation.
This field holds immense promise for both fundamental research and clinical applications.