Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

805
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
805
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.3K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.3K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.2K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.2K
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

1.3K
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
1.3K
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

1.6K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative evaluation for small molecule somatostatin 4 receptor agonists: <i>in silico</i>, <i>in vitro</i>, and <i>in vivo</i> approaches.

Frontiers in pharmacology·2026
Same author

Development of high-precision automated dynamic plantar aesthesiometer (ADPA): a promising tool in pain research.

Scientific reports·2026
Same author

TRPA1 and TRPV1 Receptors Protect the Gastric Mucosa from Ethanol-Induced Injury: Evidence from Knockout Mice.

Cells·2026
Same author

T-cell distribution in the dorsal root ganglion across species, sex, and age.

bioRxiv : the preprint server for biology·2026
Same author

Sensory nerve desensitisation exerts differential effects on the severity of acute pancreatitis in rodent models.

Life sciences·2026
Same author

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis.

British journal of pharmacology·2026

Related Experiment Video

Updated: Feb 24, 2026

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
06:04

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Published on: September 2, 2020

8.9K

Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease

Andras Garami1, Mohab Ibrahim, Kerry Gilbraith

  • 1From the Institute for Translational Medicine (A.G., E. Pakai, A.M.) and Department of Pharmacology and Pharmacotherapy (E. Pinter), Medical School, University of Pecs, Pecs, Hungary; Departments of Anesthesiology (M.I., K.G., F.P., A.M.P.), Pharmacology (M.I., K.G., R.K., F.P., A.M.P.), and Neuroscience (R.K.), University of Arizona, Tucson, Arizona; Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona (A.A.R.).

Anesthesiology
|August 15, 2017
PubMed
Summary

Transient receptor potential vanilloid 1 antagonists prevent anesthesia-induced hypothermia in rodents without causing hyperthermia. These compounds also reduce the need for opioids to manage postsurgical pain.

More Related Videos

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

3.3K
An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
06:40

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Published on: June 8, 2021

2.9K

Related Experiment Videos

Last Updated: Feb 24, 2026

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
06:04

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Published on: September 2, 2020

8.9K
Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

3.3K
An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
06:40

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Published on: June 8, 2021

2.9K

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Pain Management

Background:

  • Intraoperative hypothermia and postoperative pain are significant clinical challenges.
  • Transient receptor potential vanilloid 1 (TRPV1) is implicated in thermoregulation and pain.
  • TRPV1 antagonists were previously hindered as analgesics due to hyperthermia side effects.

Purpose of the Study:

  • To test if a preincision injection of a TRPV1 antagonist prevents anesthesia-induced hypothermia.
  • To determine if TRPV1 antagonists decrease opioid requirements for postsurgical hypersensitivity.

Main Methods:

  • Rodents (rats and mice) received general anesthesia (isoflurane or ketamine).
  • Animals were treated with TRPV1 antagonists (AMG 517 or ABT-102).
  • Core body temperature, oxygen consumption, and pain withdrawal responses were monitored.

Main Results:

  • AMG 517 and ABT-102 dose-dependently prevented anesthesia-induced hypothermia without causing hyperthermia.
  • TRPV1 antagonist efficacy in preventing hypothermia was confirmed in wild-type mice but not in knockout models.
  • A single preincision dose of AMG 517 reduced the opioid dose needed to reverse postincisional hyperalgesia.

Conclusions:

  • TRPV1 antagonists effectively prevent anesthesia-induced hypothermia in rodents.
  • TRPV1 antagonists decrease opioid requirements for managing postincisional hypersensitivity.