Related Experiment Video
Updated: Jan 9, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
14.8K
Transfusion-related immunomodulation: a reappraisal
Lyla A Youssef1, Steven L Spitalnik
1aDepartment of Microbiology & Immunology bDepartment of Pathology & Cell Biology, Columbia University, New York, New York, USA.
Current Opinion in Hematology
|August 15, 2017
Summary
Transfusion-related immunomodulation (TRIM) may be mediated by macrophages. Research should investigate immunosuppressive effects from transfused red blood cells (RBCs) and storage lesion by-products.
Area of Science:
- Immunology
- Hematology
Background:
- Transfusion-related immunomodulation (TRIM) is a complex phenomenon.
- Understanding TRIM requires integrating innate, adaptive, and nutritional immunity concepts.
Purpose of the Study:
- To review current knowledge on TRIM.
- To propose a research focus for TRIM, distinguishing effects of pure red blood cells (RBCs) from storage lesion by-products.
- To explore the role of macrophages in TRIM.
Main Methods:
- Literature review and synthesis of existing research on TRIM.
- Analysis of immunological concepts relevant to transfusion.
- Focus on macrophage biology and function.
Main Results:
- Macrophages and monocytes possess 'memory' capabilities.
- Exposure to stimuli induces epigenetic, metabolic, and functional changes in myeloid cells.
- Macrophages are key in RBC clearance and iron recycling.
Conclusions:
- Macrophages are potential mediators of TRIM.
- TRIM's immunosuppressive effects may stem from transfused RBCs and storage lesion by-products.
- Further research is needed to define specific immunosuppressive mechanisms.
Related Concept Videos
01:40Cell-mediated Immune Responses
83.3K
Overview
83.3K
02:45Blood Transfusion and Agglutination
13.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
13.9K
01:15Blood Transfusion
2.1K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.1K
01:24Tissue Transplantation
864
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
864
01:22Bone Marrow Sampling and Transplants
816
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
816
01:19Rh Blood Group
2.7K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.7K