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Circulating Progenitor Cell Response to Exercise in Wheelchair Racing Athletes.

Grace M Niemiro1, Thomas Edwards, J P Barfield

  • 11Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL; 2Department of Health and Human Performance, Radford University, Radford, VA; 3U.S. Paralympics, Colorado Springs, CO; 4Department of Physical Therapy, University of Alabama-Birmingham, Birmingham, AL; 5Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, CANADA; and 6School of Human Kinetics, Brain and Mind Research Institute, and Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON, CANADA.

Medicine and Science in Sports and Exercise
|August 15, 2017
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Summary
This summary is machine-generated.

Elite wheelchair racers show increased circulating progenitor cells (CPC) after intense exercise. CPC response is linked to cardiorespiratory fitness and exercise intensity, suggesting unique adaptations in these athletes.

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Area of Science:

  • Exercise Physiology
  • Stem Cell Biology
  • Sports Science

Background:

  • Circulating progenitor cells (CPC) are crucial for tissue repair but their mobilization in elite wheelchair athletes is unstudied.
  • Understanding CPC response in this population is vital for assessing physiological adaptations to exercise.

Purpose of the Study:

  • To investigate circulating progenitor cells (CPC) and their subpopulations mobilization in elite wheelchair racing athletes.
  • To compare CPC responses to acute upper-extremity aerobic exercise with those of ambulatory populations.

Main Methods:

  • Eight elite wheelchair racers completed a 25-km time trial.
  • Blood samples were analyzed pre- and post-exercise for CPC, HSPC, HSC, MSC, and EPC populations using flow cytometry.
  • Blood lactate levels were measured to indicate exercise intensity.

Main Results:

  • Circulating progenitor cell (CPC) concentration increased 5.7-fold post-exercise.
  • Hematopoietic stem and progenitor cells (HSPC), hematopoietic stem cells (HSC), endothelial progenitor cells (EPC), and mesenchymal stromal cells (MSC) did not significantly increase.
  • CPC, EPC, and adipose tissue-derived MSC responses correlated positively with changes in lactate, indicating intensity-dependent mobilization.

Conclusions:

  • Circulating progenitor cell (CPC) levels in wheelchair racers are associated with cardiorespiratory fitness.
  • Exercise-induced CPC mobilization in these athletes is positively related to exercise intensity.
  • Findings suggest distinct physiological responses to exercise in elite wheelchair athletes compared to ambulatory individuals.