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Related Experiment Videos

Asthma: 2. Trends in pharmacologic therapy.

A S Rebuck, K R Chapman

    CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
    |March 1, 1987
    PubMed
    Summary

    For ambulatory asthma, selective beta 2-adrenoreceptor agonists are the first-line treatment. For more severe cases, adding inhaled corticosteroids or anticholinergics improves asthma control and reduces systemic corticosteroid use.

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    Area of Science:

    • Pulmonology
    • Pharmacology

    Background:

    • Selective beta 2-adrenoreceptor agonists are the standard first-line therapy for ambulatory asthma.
    • Asthma management requires additional pharmacologic pathways for patients with more than mild severity.

    Purpose of the Study:

    • To review current and emerging therapeutic strategies for asthma management.
    • To evaluate the role of combination inhalational therapy and high-dose inhaled corticosteroids in controlling asthma.
    • To assess the efficacy of combination inhalational therapy in emergency department settings for acute, severe asthma.

    Main Methods:

    • Review of current asthma treatment guidelines and pharmacologic options.
    • Analysis of the safety and efficacy of traditional second-line agents (theophylline) versus newer inhalational agents.
    • Evaluation of combination inhalational therapy in acute, severe asthma management.

    Main Results:

    • Selective beta 2-agonists are effective for mild asthma.
    • Inhaled corticosteroids, anticholinergics, and mast cell stabilizers are increasingly used as second-line therapies due to safety concerns with theophylline.
    • Combination inhalational therapy, particularly nebulized adrenoreceptor agonist plus anticholinergic, is more effective than monotherapy in acute, severe asthma.

    Conclusions:

    • Combination inhalational therapy and high-dose inhaled corticosteroids can reduce the need for systemic corticosteroids.
    • Combination inhalational therapy is a valuable strategy for managing asthma in emergency departments.
    • Further research is needed for newer agents like xanthine derivatives, antihistamines, and calcium channel blockers.

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