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Painkiller Isoxicam and Its Copper Complex Can Form Inclusion Complexes with Different Cyclodextrins: A Fluorescence,
Sathi Goswami1, Anupa Majumdar1, Munna Sarkar1
1Chemical Sciences Division, Saha Institute of Nuclear Physics , 1/AF Bidhannagar, Kolkata - 700064, India.
The Journal of Physical Chemistry. B
|August 15, 2017
Summary
The painkiller Isoxicam and its copper complex form inclusion complexes with cyclodextrins (CDs). Gamma-cyclodextrins show the strongest binding, with Isoxicam
Area of Science:
- Pharmaceutical Chemistry
- Supramolecular Chemistry
Background:
- Isoxicam is a nonsteroidal anti-inflammatory drug (NSAID) from the oxicam group.
- Cyclodextrins (CDs) are widely used to improve drug solubility and stability.
Purpose of the Study:
- Investigate the host-guest complexation of Isoxicam and its copper complex with various cyclodextrins.
- Characterize the binding interactions in both solution and solid states.
Main Methods:
- Steady-state and time-resolved fluorescence spectroscopy
- Fluorescence anisotropy
- Proton Nuclear Magnetic Resonance (1H NMR)
- Fourier-Transform Infrared (FTIR) spectroscopy
Main Results:
- Isoxicam and its copper complex form inclusion complexes with β-CD, γ-CD, HPβCD, and HPγCD.
- Gamma-cyclodextrin (γ-CD) exhibited the strongest binding affinity.
- Isoxicam preferentially binds via its benzene ring, with deeper penetration into larger CD cavities (γ-CD, HPγCD).
- HPβCD and HPγCD showed dual binding modes: inclusion and surface interaction.
Conclusions:
- Cyclodextrin complexation significantly alters Isoxicam's interaction profile.
- The choice of cyclodextrin influences the binding mode and extent of drug penetration.
- Understanding these interactions is crucial for developing improved NSAID formulations.
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