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Temporal Changes in Thyroid Nodule Volume: Lack of Effect on Paranodular Thyroid Tissue Volume
Giorgio Grani1, Rocco Bruno2, Giuseppe Lucisano3
11 Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza , Rome, Italy .
Thyroid : Official Journal of the American Thyroid Association
|August 16, 2017
Summary
Thyroid nodule growth is a localized process, not linked to surrounding tissue expansion. This study clarifies that nodular thyroid glands should be termed "uni- or multinodular thyroid gland," distinct from goiter.
Area of Science:
- Endocrinology
- Thyroidology
- Medical Imaging
Background:
- The term "nodular goiter" implies hyperplasia of non-nodular thyroid tissue alongside nodule growth.
- This assumption has historically influenced the classification and understanding of thyroid nodules.
Purpose of the Study:
- To prospectively investigate whether thyroid nodule growth is associated with hyperplasia of surrounding non-nodular thyroid tissue.
- To differentiate between nodular thyroid gland and nodular goiter based on tissue growth patterns.
Main Methods:
- Prospective, multicenter observational study involving 992 patients with benign thyroid nodules.
- Annual ultrasound assessments of nodular and non-nodular thyroid tissue volumes over five years.
Main Results:
- Thyroid volumes remained stable in patients with stable nodules.
- Significant nodule growth correlated with increased overall thyroid volume.
- Growth was confined to the nodular tissue, with stable non-nodular tissue volume.
Conclusions:
- Thyroid nodule growth is a localized phenomenon.
- Non-nodular thyroid tissue does not exhibit compensatory hyperplasia.
- Recommends distinguishing "uni- or multinodular thyroid gland" from "uni- or multinodular goiter."
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