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Related Experiment Video

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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Maximising value from a United Kingdom Biomedical Research Centre: study protocol.

Trisha Greenhalgh1, Pavel V Ovseiko2, Nick Fahy3

  • 1Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Woodstock Rd, Oxford, OX2 6GG, United Kingdom. trish.greenhalgh@phc.ox.ac.uk.

Health Research Policy and Systems
|August 16, 2017
PubMed
Summary
This summary is machine-generated.

This study investigates how to best support partnerships within the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). Findings will accelerate knowledge translation and improve research efficiency for patient benefit.

Keywords:
Biomedical Research CentresHealth policyHealth research policyHealth technology developmentInnovation policyKnowledge productionNational Institute for Health ResearchResearch on researchResearch partnerships

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Area of Science:

  • Health Services Research
  • Translational Medicine
  • Innovation Studies

Background:

  • Biomedical Research Centres (BRCs) are key partnerships between healthcare organizations and universities in England.
  • Their mission is to drive innovation, translate discoveries into patient benefits, and enhance healthcare efficiency.
  • The NIHR Oxford BRC is entering its third funding period, necessitating research into optimizing its multi-stakeholder system.

Purpose of the Study:

  • To apply evidence on supporting partnerships within a large, multi-stakeholder research system.
  • To research the dynamics of these partnerships within a new translational research program.
  • To enhance the effectiveness and impact of the NIHR Oxford BRC.

Main Methods:

  • An organizational case study approach informed by action research principles.
  • A cross-cutting theme, 'Partnerships for Health, Wealth and Innovation,' with multiple sub-themes.
  • Utilizing theoretical models from innovation studies, sociology of science, and business studies, alongside empirical data, interviews, and ethnography.

Main Results:

  • Anticipated acceleration of knowledge translation from research to patient benefit.
  • Closer alignment of innovation processes with patient priorities and ethical research principles.
  • Reduction in research waste and enhanced understanding of multi-stakeholder research governance.

Conclusions:

  • The study is expected to significantly add value to the Oxford BRC.
  • Predicts improved efficiency, ethical alignment, and reduced waste in health research.
  • Aims to build capacity for the evolving health research landscape.