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Updated: Feb 24, 2026
Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
Published on: March 3, 2023
Personalized treatment in patients with colorectal liver metastases
Dimitrios Moris1, Timothy M Pawlik1
1Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, Ohio.
Background:
Precision Medicine Initiative is a new research effort aiming to offer personalized treatment in many diseases, including cancer. The aim of the present article is to offer novel insights about the role of personalized treatment in patients with colorectal liver metastases (CRLM).
Methods:
A review of the literature regarding personalized medicine and colorectal liver metastases was performed mainly in the MEDLINE/PubMed database.
Results:
Surgical resection remains the only hope for cure of CRLM. Improved surgical strategies to optimize remnant liver volume are recently introduced and gaining ground. Following resection of CRLM scoring systems have been developed by combining certain preoperative factors such as microsatellite instability KRAS expression and sensitivity to immunotherapy with Programmed Death-1 inhibitor.
Conclusions:
Multidisciplinary management of patients with CRLM has markedly contributed to increased survival. While the last several decades have been characterized by these important developments, future advances for patients with CRLM will depend on a better understanding of genomics and molecular biology to facilitate characterization of a specific tumor "identity" so that individualized treatment for each CRLM patient becomes the rule, and not the exception.
Insights
Personalized medicine offers tailored treatments for colorectal liver metastases (CRLM). Advances in genomics and molecular biology are key to individualized care, improving survival for CRLM patients.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- The Precision Medicine Initiative aims to personalize cancer treatment.
- Colorectal liver metastases (CRLM) are a significant clinical challenge.
- Understanding personalized treatment roles in CRLM is crucial.
Purpose of the Study:
- To provide novel insights into personalized treatment for colorectal liver metastases (CRLM).
- To review the current literature on personalized medicine and CRLM.
Main Methods:
- Literature review conducted on MEDLINE/PubMed.
- Focus on personalized medicine strategies for CRLM.
Main Results:
- Surgical resection is the primary curative option for CRLM.
- New surgical techniques optimize remnant liver volume.
- Scoring systems integrate preoperative factors (microsatellite instability, KRAS, immunotherapy sensitivity) for CRLM management.
Conclusions:
- Multidisciplinary management improves CRLM patient survival.
- Future CRLM advances depend on understanding tumor genomics and molecular biology.
- Individualized treatment based on tumor identity is the future goal for CRLM patients.
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