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Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

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The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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The Mammary Glands01:12

The Mammary Glands

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The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
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Exocrine Glands: Unicellular and Multicellular Glands01:29

Exocrine Glands: Unicellular and Multicellular Glands

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Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Related Experiment Video

Updated: Feb 24, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
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Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

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Bartholin gland cancer.

Violante Di Donato1, Assunta Casorelli1, Erlisa Bardhi1

  • 1Department of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, Italy.

Critical Reviews in Oncology/Hematology
|August 16, 2017
PubMed
Summary
This summary is machine-generated.

Bartholin gland carcinoma is rare, with squamous cell carcinoma, adenoid cystic carcinoma, and adenocarcinoma as common types. Adenocarcinoma histotype and positive lymph nodes indicate a worse prognosis for this challenging cancer.

Keywords:
Bartholin gland cancerBartholin gland carcinomaGreater vestibular glands cancerMajor vestibular glands cancer

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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

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Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
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Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

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Related Experiment Videos

Last Updated: Feb 24, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
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Area of Science:

  • Gynecologic Oncology
  • Rare Cancers
  • Pathology

Background:

  • Bartholin gland carcinoma is an extremely rare malignancy.
  • Lack of phase III trials results in no consensus on treatment or established guidelines.

Purpose of the Study:

  • To review and analyze existing literature on Bartholin gland carcinoma.
  • To identify prognostic factors and understand the challenges in managing this rare cancer.

Main Methods:

  • Systematic collection and screening of all published studies reporting Bartholin cancer cases.
  • Extraction and database querying of baseline study characteristics.

Main Results:

  • A review of 133 manuscripts representing 275 reported cases.
  • Histological types: 30.7% squamous cell carcinoma, 29.6% adenoid cystic carcinoma, 25% adenocarcinoma.
  • Multivariate analysis revealed adenocarcinoma histotype and positive lymph nodes correlate with worse prognosis.

Conclusions:

  • Bartholin gland cancer presents a significant challenge for gynecologic oncologists.
  • Centralization of care to referral centers and multi-institutional trials are crucial for advancing understanding and treatment.