Related Experiment Video
Updated: Feb 24, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
Published on: July 3, 2020
Is osteocyte Klotho bad for bone health?
Rosa M A Moysés1, Adriana Dusso2
1Medicine master's degree program, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil; Nephrology Division, Universidade de São Paulo, São Paulo, Brazil.
Abstract:
The recent identification of αKlotho protein (Klotho) in osteocytes led to the generation of an experimental mouse model with osteocyte-specific Klotho ablation. This enabled Komaba et al. to assess the contribution to bone structure and function of osteocyte Klotho per se as compared with that of the systemic fibroblast growth factor 23-Klotho axis. Surprisingly, unlike the osteopenia and low bone turnover of systemic Klotho deletion, osteocyte-specific Klotho ablation resulted in increased osteoblastic activity and bone formation rate.
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