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Related Experiment Video

Updated: Feb 24, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

41.4K

Murine models for mucosal tolerance in allergy.

Ursula Smole1, Irma Schabussova2, Winfried F Pickl1

  • 1Institute of Immunology, Center for Pathophysiology, Infectiology, and Immunology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Seminars in Immunology
|August 16, 2017
PubMed
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Mucosal tolerance maintains immune balance against harmless antigens like food and allergens. Research advances understanding and develops new strategies for allergy vaccines, improving immune responses.

Area of Science:

  • Immunology
  • Allergy Research
  • Mucosal Immunology

Background:

  • Immunity requires discriminating self from non-self.
  • Mucosal surfaces induce tolerance to commensals and environmental antigens.
  • Understanding mucosal tolerance has advanced significantly.

Purpose of the Study:

  • To review basic mechanisms of mucosal tolerance.
  • To contrast gut and respiratory lymphoid tissues in tolerance.
  • To highlight current strategies for improving mucosal tolerance in allergy.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of cellular and molecular players in mucosal tolerance.
  • Examination of prophylactic and therapeutic models for allergy vaccines.
Keywords:
AllergyAnimal modelsBALTCommensalsGALTMucosal toleranceNALTRegulatory T cells

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Related Experiment Videos

Last Updated: Feb 24, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

41.4K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

588
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

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Main Results:

  • Significant expansion in understanding mucosal tolerance mechanisms.
  • Development of promising models for tolerance induction against innocuous antigens.
  • Introduction of improved formulations and adjuvants for allergy vaccines.

Conclusions:

  • Mucosal tolerance is crucial for immune homeostasis.
  • Interdependence exists between gut and respiratory lymphoid tissues.
  • Further strategies are needed to optimize mucosal tolerance induction for allergy management.