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Evaluation of the Antidiabetic Properties of S-1708 Mulberry Variety

Brijesh Ranjan1, Randhir Kumar2, Neeraj Verma3

  • 1Department of Applied Animal Sciences, Sericulture Laboratory, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India.

Pharmacognosy Magazine
|August 16, 2017
PubMed
Abstract

Insights

Mulberry leaf extract, rich in antioxidants, significantly reduced blood glucose levels and improved liver health in diabetic mice. This study highlights the therapeutic potential of the S-1708 mulberry variety for managing diabetes and its complications.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Metabolic Disorders

Background:

  • Diabetes mellitus is a global metabolic disease linked to oxidative stress from free radicals.
  • Antioxidants are crucial for combating oxidative stress and managing diabetes.

Purpose of the Study:

  • To evaluate the antioxidant and antidiabetic effects of mulberry leaf extract.
  • To assess the therapeutic potential of the S-1708 mulberry variety in diabetic mice.

Main Methods:

  • Antioxidant activity was measured using 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and ferric reducing/antioxidant power (FRAP) assays.
  • Diabetic mice were orally administered mulberry leaf extract for three weeks.
  • Enzyme activities and liver histology were analyzed post-treatment.

Main Results:

  • Mulberry leaf extract exhibited potent in vitro antioxidant activity, surpassing ascorbic acid.
  • Diabetic mice showed a significant decrease in blood glucose (-71.58%) and an increase in body weight (+25.88%).
  • Key enzyme activities (glucose-6-phosphate dehydrogenase, catalase) normalized, and liver histology indicated hepatocyte regeneration.

Conclusions:

  • The S-1708 mulberry variety demonstrates significant therapeutic potential for diabetes.
  • Mulberry leaf extract effectively combats oxidative stress and improves metabolic parameters in diabetic models.
  • This study supports the use of mulberry as a natural remedy for diabetes and related complications.
Keywords:
22-diphenyl-1-picryl-hydrazylantioxidantferric reducing/antioxidant powermulberrystreptozotocin

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