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Lycium Barbarum Polysaccharides Decrease Hyperglycemia-Aggravated Ischemic Brain Injury through Maintaining

Wen-Jing Liu¹, Hai-Feng Jiang¹, Faisal Ul Rehman¹

¹School of Basic Medical Science, Ningxia Key Laboratory of Cerebrocranial Diseases-Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan 750004, China.

International Journal of Biological Sciences

|August 16, 2017

Summary

Lycium barbarum polysaccharides (LBP) protect the brain from damage caused by high blood sugar during stroke. LBP treatment reduced neurological deficits and brain injury in hyperglycemic rats, suggesting a role in maintaining mitochondrial balance.

Keywords:

Lycium barbarum polysaccharides cerebral ischemia and reperfusion dynamin-related protein 1 hyperglycemia mitochondrial fission/fusion neuroprotection optic atrophy 1.

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Area of Science:

Neuroscience
Biochemistry
Pharmacology

Background:

Polysaccharides from Lycium barbarum (LBP) are known for neuroprotective properties.
The effect of LBP on hyperglycemia-aggravated ischemia/reperfusion brain injury remains largely unknown.

Purpose of the Study:

To investigate the efficacy of LBP in ameliorating hyperglycemia-aggravated ischemia/reperfusion brain injury in a rat model.
To explore the role of mitochondrial dynamics, specifically Opa1 and Drp1 proteins, in this process.

Main Methods:

Middle cerebral artery occlusion (MCAO) model in normoglycemic (NG) and hyperglycemic (HG) rats.
HG rats were pretreated with LBP or insulin.
Assessment of neurological deficit, infarct volume, pathohistology, and expression of Opa1 and Drp1 proteins via immunohistochemistry and Western blot.

Main Results:

Hyperglycemic rats exhibited increased neurological deficits, infarct volume, and neuronal pyknosis compared to normoglycemic rats.
LBP pretreatment significantly reduced these hyperglycemia-induced negative effects.
Hyperglycemia altered mitochondrial dynamics by increasing Drp1 and decreasing Opa1 expression, which LBP treatment reversed.

Conclusions:

Hyperglycemia exacerbates ischemia/reperfusion brain injury, partly through altering mitochondrial dynamics.
Lycium barbarum polysaccharides demonstrate a therapeutic potential in mitigating hyperglycemia-enhanced ischemic brain damage by preserving mitochondrial balance.