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Targeting Adult Neurogenesis for Poststroke Therapy
Jianfei Lu1,2, Anatol Manaenko3, Qin Hu1
1Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Stem Cells International
|August 16, 2017
Summary
Stroke activates neural stem cells (NSCs) in the brain, but newborn neurons often die. Enhancing this neurogenesis and promoting neuron survival offers potential stroke repair therapies.
Area of Science:
- Neuroscience
- Stem Cell Biology
- Regenerative Medicine
Background:
- Adult neurogenesis occurs in the subventricular zone (SVZ) and subgranular zone (SGZ).
- Most new neurons undergo programmed cell death (PCD) during development.
- Stroke triggers neural stem cell (NSC) activation in the SVZ and SGZ.
Purpose of the Study:
- To provide an overview of adult neurogenesis.
- To explore the potential of stroke-induced neurogenesis for brain repair.
- To highlight therapeutic strategies for stroke recovery.
Main Methods:
- Review of existing literature on adult neurogenesis and stroke.
- Analysis of signaling pathways regulating neurogenesis.
- Discussion of therapeutic interventions.
Main Results:
- Stroke activates endogenous neural stem cells (NSCs).
- Newborn neurons from adult neurogenesis are insufficient for complete tissue repair.
- Programmed cell death (PCD) significantly reduces the number of surviving new neurons.
Conclusions:
- Enhancing stroke-induced neurogenesis is a promising therapeutic avenue.
- Promoting the survival of newborn neurons is crucial for functional recovery after stroke.
- Targeting adult neurogenesis pathways may lead to novel stroke treatments.
