Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

894
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
894
Mitochondria01:37

Mitochondria

21.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.9K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.9K
Human Genetics01:28

Human Genetics

1.7K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.7K
Epigenetic Regulation01:37

Epigenetic Regulation

4.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.0K
Epigenetic Regulation01:46

Epigenetic Regulation

34.0K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Applications of Liquid Biopsy in Colorectal Cancer: A Focus on Registered Clinical Trials.

Genes·2026
Same author

Altered immune and treatment response gene expression signatures among povertyexposed children with B-cell acute lymphoblastic leukemia.

Haematologica·2026
Same author

Altered immune and treatment response gene expression signatures among poverty-exposed children with B-ALL.

bioRxiv : the preprint server for biology·2026
Same author

Genome-wide methylation analysis of circulating cell-free DNA identifies an episignature in lung cancer: validation of EMP2 as a potential biomarker.

Clinical epigenetics·2025
Same author

Electron Capture-Induced Charge Reduction Benefits the Recording of Ultralong Transients in Orbitrap-Based Individual-Ion Mass Spectrometry.

Analytical chemistry·2025
Same author

Differential performance of strategies for single-cell whole-genome amplification.

Cell reports methods·2025

Related Experiment Video

Updated: Feb 24, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K

Epigenetics and Oxidative Stress in Aging.

Amy Guillaumet-Adkins1, Yania Yañez2, Manuel D Peris-Diaz3

  • 1CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

Oxidative Medicine and Cellular Longevity
|August 16, 2017
PubMed
Summary
This summary is machine-generated.

Aging involves cellular damage from free radicals and epigenetic changes. This review explores how oxidative stress and epigenetics interact to drive age-related decline and disease vulnerability.

More Related Videos

Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis
09:47

Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis

Published on: June 2, 2023

3.4K
Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

7.9K

Related Experiment Videos

Last Updated: Feb 24, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K
Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis
09:47

Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis

Published on: June 2, 2023

3.4K
Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

7.9K

Area of Science:

  • Gerontology and Molecular Biology
  • Investigating the biological mechanisms of aging.

Background:

  • Aging is a complex process marked by declining physiological functions and increased disease susceptibility.
  • Free radical damage from mitochondrial metabolism is a prominent theory for cellular aging.
  • Epigenetic modifications, including DNA methylation and noncoding RNAs, are increasingly recognized as crucial in aging.

Purpose of the Study:

  • To review the role of oxidative stress and epigenetic modifications in aging.
  • To explore the interplay between these factors in age-related functional decline.

Main Methods:

  • Literature review of existing research on aging mechanisms.
  • Analysis of evidence linking oxidative stress and epigenetic alterations.
  • Synthesis of findings to propose a unified explanation for aging.

Main Results:

  • Oxidative stress contributes to cellular and DNA damage, a known aging factor.
  • Epigenetic changes like DNA methylation and histone modifications are critical molecular drivers of aging.
  • The interaction between oxidative stress and epigenetic alterations provides a comprehensive framework for understanding aging.

Conclusions:

  • Both oxidative stress and epigenetic modifications are key contributors to the aging process.
  • The combined effects of these factors explain age-related functional decline and increased disease risk.
  • Further research into the interplay of epigenetics and oxidative stress may reveal therapeutic targets for age-related conditions.